[4] As a nobleman,[5] he was possibly the "D. Jorge de Meneses" present at the His Most Faithful Majesty's Council of Manuel I of Portugal in 1518 and 1519.
[6] In 1526, Menezes traveled to Brunei, detailing the city as being fortified by a brick wall and having a moderate number of notable buildings.
[9] Successor to Antonio de Brito,[10] Menezes was the Portuguese Governor of the Moluccas [pt] from 1527 until 1530, residing in Ternate.
[11] On 22 August 1526, he left Portuguese Malacca[12] with 100 men[13] to take his post but was sidetracked by a monsoon, leading to his discovery of New Guinea; he arrived in Ternate on 31 May 1527.
[5][19] He captured indigenous people and enslaved them on his sesmaria [pt],[19] provoking an attack that temporarily destroyed the captaincy and eradicated the colonists in 1537.