José Francisco Gana López (November 13, 1791 – January 20, 1864) was a Chilean military officer and politician, who took part in the Peruvian War of Independence.

Gana with his battalion captured the City of Huaras with the whole garrison, and, as a consequence, the provinces of Trujillo, Lambayeque, and Piura pronounced for the insurrection, leading to the whole northern portion of Peru being wrestled from the rule of the viceroy.

Gana participated in General Sucre's expedition to the south, and commanded a column that attacked the Spanish forces at Quilca (August 14, 1823), and, notwithstanding the loss of one third of his troops, routed the enemy and pursued him toward Arequipa.

In October 1823, Gana returned to Chile, and in 1825 was sent with his battalion under Colonel Sanchez to garrison the city of Talca against the attacks of the bands of the Pincheira brothers, whom he surprised and defeated.

During the Chilean Civil War of 1829, he joined the liberal forces under General Ramón Freire, and, after their defeat at the Battle of Lircay (April 17, 1830) declined to serve under the government of the conservatives, and retired from active service.