José Manuel Serrano Arenas (born 17 March 1981) is a Spanish former footballer who played as a defender.

After spending four years with local Sevilla FC's reserves, without any first-team appearances, he stayed one season with neighbouring Segunda División side Xerez CD and then switched to Levante UD.

Initially, Serrano played almost exclusively with the reserves in the Segunda División B, making his first-team and La Liga debut aged almost 26 in a 2–4 home defeat against Sevilla on 28 January 2007.

[1] The following campaign, he scored in a 1–5 home loss to Valencia CF as Levante were already relegated.

[2] For 2008–09, Serrano joined Madrid club Rayo Vallecano, recently returned to the second division, appearing in only 20 league games out of 84 over the course of two years and being released, after which he signed a two-year contract with Cádiz CF, returning to his native region.