José Guillermo Santiago Guzmán (September 4, 1928 – October 9, 2018),[1] better known by the nickname "Pantalones", was a Puerto Rican professional baseball pitcher who played in Major League Baseball between 1954 and 1956 for the Cleveland Indians (1954–1955) and Kansas City Athletics (1956).

Born in Coamo, he was listed at 5 feet 10 inches (1.78 m) tall and 175 pounds (79 kg), he batted and threw right-handed.

During his three MLB trials, Santiago posted a 3–2 record with 29 strikeouts and a 4.66 ERA in 27 appearances, including five starts and 56 innings of work, allowing 67 hits and 33 bases on balls.

[2][3] A believer in Puerto Rican Independence, Santiago, like his friend Fufi Santori, owned a technically possible, Puerto Rican passport, in his case numbered #001261, since 1997.

This biographical article relating to a Puerto Rican baseball pitcher is a stub.