At the early age of 11 he had already joined the Capital Police marching band and was a student of composer Félix Fernández and director Salvador Déntice.
[1]In 1928 he met the Guairá-native poet Manuel Ortiz Guerrero, and soon after the two started working together to create the most beautiful Guaranias songs to date such as India, Cerro Corá and Panambí Verá.
While he was living in Argentina his songs were diffused throughout Paraguay and the Guarania genre became a success, confirming the originality and creativity of Flores' work.
While living in Buenos Aires, Flores also worked on classical music and wrote twelve symphonies in his lifetime.
His wish to return to his home country was even denied in the latter years of his life when he was ill and wanted to see his homeland and people one more time before his death.