José Santos Guardiola Bustillo (1 November 1816 – 11 January 1862) was a two-term President of Honduras.

His good relations with the British helped facilitate the return of governance of the Bay Islands and the La Mosquitia region into Honduras.

He struck a deal with Queen Victoria on which Great Britain recognized the Honduran sovereignty of the aforementioned territories (the treaty of Wyke-Cruz) as long as the inhabitants of the islands were granted freedom of worship.

Pablo Agurcia became the new head and proceeded to change the guards of the president in order to kill him.

The provisional president, José María Medina, ordered a court to hear the case and the suspects were sentenced to death.