In July 2013 he fought former title contender Ricardo Dominguez and won by TKO in the 3rd round.

On 11 July 2015, Zepeda fought Terry Flanagan in Manchester, England, for the vacant WBO lightweight title.

[1] In February 2019, he unsuccessfully challenged WBC Super lightweight champion Jose Ramirez for his title, losing a Majority decision in a very competitive fight.

[2] In his bout against Jose Pedraza, Zepeda started off fast and built up an early lead on the scorecards.

In the end, Zepeda was too much for his opponent, and was awarded a clear unanimous decision victory.