Agassi was born into a Haredi family who lived in Jerusalem's Buchari neighborhood.

An advocate of Popper's philosophy with variations, Agassi ignored many of the problems that concern some philosophers of science, chiefly that of theory choice.

Agassi had expressed criticism against the settler movement and advocated for Israel to "separate" from the worldwide Jewish community: The flimsy excuse – the notion that Israel belongs to the Jewish people and not to the Israeli nation – is the very threat to its independence.

[3]He was close to Hillel Kook who advocated severely limiting the Right of Return, forming a Hebrew Nation and creation of a Constitution already in 1948.

His demands from those who design global politics are minimalist: small methodological changes may lead to large-scale achievements.