[1][2][3] Graduating as Notary Public from the University of Malta in 1978 and as Doctor of Laws in 1979, Azzopardi was the first president of the Federation of Maltese Youth Organizations in 1980.
[4] On 23 May 2003, Azzopardi was appointed by Prime Minister Eddie Fenech Adami (PN) as Judge of the Superior Courts.
[4] In April 2018, at 63, Azzopardi was appointed by Prime Minister Joseph Muscat (PL) as Chief Justice of Malta.
[5] In October 2019, he used the occasion of the annual speech to lash out against journalists for asking compromising questions, saying that "it is easy to attack members of the judiciary because you know they can’t answer you".
[7] On 8 March 2023 Azzopardi was appointed Commissioner for Standards in Public Life, succeeding Dr George Marius Hyzler in this role.