He devoted much of his life to freeing Christian slaves in North Africa, and was regarded as one of the leading experts of his time on Morocco and the Sahara.
The British consul at Mogador was well known for paying high prices to free Christian slaves in North Africa.
During his tenure as British vice-consul in Mogador, Dupuis secured the freedom of many Christian sailors from the hardships of slavery, and in many cases, death.
Dupuis partnered a successful mercantile establishment that was engaged in trading between Mogador and Great Britain with William Willshire.
Upon making note of Adams in his historical record on October 6, 1813, Dupuis wrote that "Like most other Christians after a long captivity and severe treatment among the Arabs, he appeared on his first arrival exceedingly stupid and insensible; and he scarcely spoke to anyone."