Joseph Finch Guffey (December 29, 1870 – March 6, 1959) was an American business executive and Democratic Party politician from Pittsburgh, Pennsylvania.

Joseph Guffey was the last born of eight children: brothers James C. and Alexander S, and sisters Ida Virginia, Pauletta, Mary Emma, Jane Campbell, and Elizabet Irwin.

[8] On December 28, 1922, he was indicted by a federal grand jury on twelve counts of embezzlement through misappropriation of funds that he managed during his service as Director of the Bureau of Sales.

Joseph Patrick Tumulty, former President Wilson's personal secretary and Guffey's attorney asserted that all allegation against his client were politically motivated.

[citation needed] Guffey spoke out against Harry Anslinger (who had been appointed to lead the newly formed Federal Bureau of Narcotics by his father-in-law Andrew Mellon) for referring to "niggers" in official correspondence.

Guffey was at the same time working with Lewis, demanding that Pleas E. Greenlee replace Charles F. Hosford Jr. who had been ineffective as chairman of the National Bituminous Coal Commission.

In April 1943, British scholar Isaiah Berlin wrote a confidential analysis of the Senate Foreign Relations Committee for the British Foreign Office, and characterized Guffey as:... a noisy Administration supporter who wraps himself in the Roosevelt flag and has been advocating for a fourth term for some time.

A very typical Pennsylvania politician who has decided to throw his lot in with the President and has thus become an obedient party hack not of the purest integrity.

Joseph Guffey papers are preserved at Washington & Jefferson College, Washington, Pa., Princeton University Library, Princeton, NJ., Claude Pepper Center at Florida State University Library (text of campaign speech given March 11, 1940), and National Archives at College Park, Md.