Louis Edward Graham (August 4, 1880 – November 9, 1965) was an American politician who was a Republican member of the U.S. House of Representatives from Pennsylvania.

He served as chief legal adviser of the former sixth Federal prohibition district from 1927 to 1929, and served as U.S. Attorney for the Western District of Pennsylvania from November 7, 1929, to September 1, 1933.

He was special assistant to the United States Attorney General in the Pittsburgh vote-fraud cases (1934–1936).

He was Chairman of the United States Joint Committee on Immigration and Nationality Policy during the Eighty-third Congress.

He was an unsuccessful candidate for reelection in 1954, defeated by Democrat Frank M. Clark.