He was the son of physician Johann Peter Frank.
He assisted his father in Pavia and Vienna, and became in 1804 a professor of pathology at Vilnius University.
He was one of the more influential advocates of the Brunonian system of physic, and published "Grundriss der Pathologie nach den Gesetzen der Erregungstheorie" (Vienna, 1803).
As his career progressed, however, he became highly critical of Brunonianism.
[2] His "Praxeos Medicæ Universæ Præcepta" (Leipzig, second edition, 1826–43) has been translated into German (9 volumes, 1828–43) and French.