He carried out archaeological and architectural research in Rome, Greece, Egypt, and Syria, often in the company of Henry Parke and Frederick Catherwood.
In 1829 he published an engraved map of Nubia, showing the area between the first and second cataracts of the Nile, from a survey made in 1824 jointly by him and Parke, and a map of the city of Jerusalem; his plan of the church of the Holy Sepulchre, Jerusalem, with his drawings of the Jewish tombs in the valley of Jehoshaphat, was published by Robert Willis in 1849.
In 1828 he planned and carried out the building of Gloucester Terrace, Regent's Park, for which John Nash supplied the general elevation.
[1] His design for the church of St John in Duncan Terrace, Islington – a neo-Romanesque brick building with stone facings[4] – was censured by Pugin in an article on "Ecclesiastical Architectures" in the Dublin Review in 1843.
[1] The eldest was Ignatius Scoles who followed his father as an architect, then joined the Jesuits and designed Georgetown City Hall and St Wilfrid's Church, Preston.
[8] His third son was Alexander Joseph Cory Scoles who became a Roman Catholic priest and canon and followed his brother and father in becoming an architect.