Joseph Simon (1712–January 24, 1804) was the leader of the Jewish community in Lancaster, Pennsylvania, during the eighteenth century.
At this time Lancaster had enough Jewish men living in the community to support a minyan, and religious services were held at Simon's house.
Simon was a successful trader and owned enormous tracts of land in the West; among others, he was a business partner of William Henry—a gunsmith, merchant, and, later, important patriot during the American Revolution.
In 1767, Thomas Barton, rector of St. James' Church in Lancaster, described Simon to Sir William Johnson as "a worthy, honest Jew and principal merchant of this place...
Simon died on January 24, 1804, in Lancaster, Pennsylvania and was buried at Shaarai Shomayim Cemetery.