In 1928 Joseph Sipendi attended the minor seminary in Kilema.
From 1937 to 1945 Sipendi studied in Rome, where he obtained degrees in Catholic theology and canon law He received the Sacrament of Holy Orders on December 20, 1942.
On January 11, 1968, Pope Paul VI appointed him Bishop of Moshi.
The bishop of Bukoba, Laurean Cardinal Rugambwa, conferred episcopal consecration on him on 24 March of the same year at Christ the King Cathedral in Moshi; his Co-consecrators were the Archbishop of Tabora, Marko Mihayo, and the Bishop Emeritus of Moshi, Joseph Kilasara, CSSp.
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