Brought up in Salonica, he studied under Rabbi Samuel de Medina and became head of the Talmudic school there; among his pupils were Aaron Hazzan, Meir Melammed, and Shabbethai Jonah.
Ibn Ezra was a Talmudist who wrote: Rosh Yosef, a commentary on the Turim, of which the part treating of communal taxes and contributions was published at Salonica (1601), under the title Massa Melekh; Atzamot Yosef, commentary on Kiddushin (ib.
In the preface to the latter the author states that the object of the commentary is to give, in addition to the ordinary exposition of the text (peshat), a clear, insight into the methodology of the Talmud.
He states further that the responsa of Joseph ibn Leb (1576), which reached him after he had finished his commentary, compelled him to make some changes therein.
Ibn Ezra also wrote: a commentary on Bava Metzia, mentioned in the Azamot Yosef; rules for the interpretation of the Talmud; responsa, some of which are found in the Atzamot Yosef, the responsa of Salomon ha-Kohen, Samuel de medinas Beno Shemuel, and the Shai la-Mora of Shabbethai Jonah.