[3] He grew up in a well-known family in and around Palm Desert, California; his paternal grandfather, Clancy "Cap" Homme, moved to the area from North Dakota and was an early settler of the Valley.

[4] In 1987, when he was 14 years old, Homme formed a punk rock-influenced heavy metal band in Palm Desert High School called Katzenjammer with schoolmates John Garcia, Brant Bjork, Nick Oliveri and Chris Cockrell.

Kyuss released four albums (Wretch, Blues for the Red Sun, Welcome to Sky Valley, and ...And the Circus Leaves Town), of which the final three Goss-produced efforts are often cited as cornerstones to the development of the stoner rock genre in the 1990s.

Shortly after recording, Homme and Hernandez were joined by bassist and vocalist Nick Oliveri and guitarist, keyboardist, and lapsteel player Dave Catching, the band was now composed entirely of ex-Kyuss members and roadies.

The album centers on Homme's memories of uncomfortable rides through the California desert, where he had performed in his days with Kyuss, and where there was little to do but listen to Spanish radio stations.

On June 4, 2013, after a tumultuous writing and recording process, Queens of the Stone Age released their sixth album, ...Like Clockwork, receiving high praise from critics,[25] as well as topping the Billboard 200 charts.

...Like Clockwork highlights Homme's collaborative recording process and features guests such as Elton John, Dave Grohl, Alex Turner, Jake Shears, Trent Reznor, Mark Lanegan, Nick Oliveri and Brody Dalle.

Homme founded The Desert Sessions in 1997 at the Rancho De La Luna in Joshua Tree, California, describing it as a musical collective series "that cannot be defined".

[citation needed] In 1998, Homme formed Eagles of Death Metal with friend Jesse Hughes as a joke band in the context of the Desert Sessions.

Due to his commitments with Queens of the Stone Age and other projects, Homme does not regularly tour with Eagles of Death Metal, but occasionally makes appearances during live performances.

[28][29] Though initially conceived as solely a studio project, the trio performed their first show together on August 9, 2009, in Chicago at The Metro to a crowd of approximately 1,100 ticketholders with additional live rhythm guitarist/auxiliary man Alain Johannes.

[31] The band launched a world tour including performing on Saturday Night Live as a musical guest on February 6, 2010, and at Austin City Limits on October 2, 2009, as well as many festivals through 2010.

Homme has collaborated with acts such as Mondo Generator, Foo Fighters, PJ Harvey, Fatso Jetson, Mark Lanegan Band, Trent Reznor, Masters of Reality, Millionaire, Wellwater Conspiracy, Unkle, Primal Scream, Melissa Auf der Maur, Paz Lenchantin, Run the Jewels, Death from Above 1979, Earthlings?, Mastodon, Peaches, Lady Gaga, The Strokes, Local H, Biffy Clyro, Royal Blood, and Arctic Monkeys.

In May 2012, it was revealed on Dean Delray's comedy podcast Let There Be Talk that Homme would make a guest appearance on the album by Oliveri's project Mondo Generator called Hell Comes To Your Heart.

In early 2013, Homme and fellow Queens contributors Alain Johannes and Chris Goss added three tracks each to the soundtrack of Dave Grohl's documentary Sound City: Real to Reel.

Homme was interviewed for the documentary and is notably included in a scene where he collaborates with Grohl and Trent Reznor, under the name Sound City Players, to come up with a song called "Mantra".

The star of the show, Matt Berry, had been working alongside Morgana Robinson (the half-sister of Homme's ex-wife Brody Dalle) in the BBC sitcom House of Fools, in which both had prominent roles.

The band made their debut on January 21, 2016, on The Late Show with Stephen Colbert, announcing the album, and proceeded on a North American and European theater tour that March, culminating in a performance at the Royal Albert Hall, filmed and released as a concert DVD.

[54] In 2024, Homme recorded a guitar part in his home studio and sent it to Ukraine for inclusion in "Chaplain", a song by Ukrainian soldier Oleksandr Remez who is otherwise best known as the frontman of the rock band Ruky'v Bryuky; produced by Oleksandr Chemerov, the rest of the song was recorded in a mobile studio on the frontlines of the Russo-Ukrainian War as part of the Cultural Forces project to promote military music culture.

He explained in June 2007, "I don't [share secrets] only because my sound is important to me and I've spent a lot of years just working it over with little tricks here and there, I almost feel like if you reveal too much of that you give away something that's near and dear to you.

[65][66] In 2013, Homme co-founded the Sweet Stuff Foundation, a charity that aims to give assistance to musicians, recording engineers, and their families struggling with illness and disability.

[67] Homme met Australian singer and musician Brody Dalle at Lollapalooza in 1996, when he was 23 and she was 17; he was there to perform with Screaming Trees, while she was there to see her then-boyfriend Tim Armstrong's band Rancid.

[81][82] Despite this, he referred to then-president Donald Trump as a "retarded human being" in June 2017[6] and began collaborating more with notably left-leaning artists such as Run the Jewels in the late 2010s.

He used the name "Carlo Von Sexron" to credit his bass, keyboard, piano, and drums playing on albums such as The Desert Sessions Volumes 3 & 4, Queens of the Stone Age, and Peace, Love, Death Metal.

On his knuckles, he has his grandparents' nicknames ("Cam" for "Camille" on the left and "Cap" on the right) with hearts and his two sons' names ("ORH" for "Orrin Ryder Homme" and "Wolf").

[96] In June 2017, Homme revealed on Steve Jones' radio show that he had recently tried to quit his decades-long smoking habit via hypnotherapy, but claimed that it failed because he was unable to relax enough to be fully influenced by the hypnotherapist.

[99] In July 2024, during the European leg of The End Is Nero World Tour, Queens of the Stone Age postponed a concert in Italy as Homme was forced to return to the U.S. for emergency surgery of an undisclosed nature.

Pleading no contest, he was ordered to remain at least 100 yards away from Dahlia and the club, sentenced to three years' probation with community service, and forced to enter a rehab program for 60 days.

[108] Reaction to his apology was mixed, with music journalist Tim Jonze stating, "Attempting to prove his pro-gay stance, Homme points out in his letter that he also called the guy a pussy and threatened to have anal sex with him.

"[111] In December 2017, Homme was captured on video kicking the camera of Shutterstock photographer Chelsea Lauren into her face during KROQ's Almost Acoustic Christmas concert in Los Angeles.