In 2007, Fertita joined Queens of the Stone Age to replace the late Natasha Shneider on keyboards and occasionally guitar on some songs.

In 1997 Fertita formed the power pop band The Waxwings[1] along with bassist Kevin Peyok, drummer James Edmunds and guitarist Dominic Romano.

[7] Fertita cites Benson as a big influence, inspiring him to focus more energy on song writing instead of loud riffs.

[7] When Benson formed The Raconteurs Fertita was recruited to play keyboards and organ on the tour in support of the Broken Boy Soldiers album.

[9] In 2007, Hutch asked Fertita to join the Queens of the Stone Age as their new keyboardist and additional guitarist, replacing the late Natasha Shneider.

[11] On August 16, 2008, Queens of the Stone Age performed a concert in celebration of Natasha Shneider's life at the Henry Fonda Theatre in Los Angeles.

They were joined on stage by Alain Johannes, Jack Black, Kyle Gass, Matt Cameron, Brody Dalle, Jesse Hughes, Chris Goss and PJ Harvey, playing a variety of QOTSA and non-QOTSA songs.

In 2009 the members of the band took time off and were involved in a variety of other projects, but reconvened in the summer of 2010 to play a number of shows in support of a reissue of Rated R which was released on August 3.

[7] In 2010, Fertita re-recorded the Waxwings song "Different Plane" for the Novalis radiosurgery "Shaping Cancer Care Around You” national television commercial, currently running in the United States.

[20] On November 4, 2022 TROPICAL GOTHCLUB – the new project from renowned musician and multi-instrumentalist Dean Fertita -released its self-titled debut LP via Third Man Records at all DSPs and streaming services.

“I’m hoping the framework is in place with TROPICAL GOTHCLUB that I can experiment with releasing art and music in the future without following the conventional cycles.

With Queens of the Stone Age Fertita has been seen playing a Moog Little Phatty Synthesizer and a Clavia Nord Electro 2 through a set of Peavey amplifiers.

For guitars, he has used a Gibson SG and Maton BB1200 through an Ampeg combo, but was seen playing a Yamaha hollowbody through a Fender Twin Reverb amplifier on their most recent tour.