[4] Lowe was selected by the Tampa Bay Rays with the 13th pick in the first round of the 2016 Major League Baseball draft.

Lowe spent 2017 with the Bowling Green Hot Rods where he batted .268 with eight home runs, 55 RBIs, and 22 stolen bases in 118 games, and he spent 2018 with the Charlotte Stone Crabs where he hit .238 with six home runs, 47 RBIs, and 18 stolen bases in 105 games.

[6] He was selected to play in the Arizona Fall League for the Salt River Rafters following the season.

[9] In his debut, Lowe had a walk and a stolen base before collecting his first career hit, singling off of Boston Red Sox starter Nathan Eovaldi.

[10] On April 30, 2022, Lowe hit his first career home run off of Dylan Bundy of the Minnesota Twins.