In 2014, he worked with the San Francisco-based nonprofit LightHouse for the Blind and Visually Impaired to start using TMAP to produce tactile maps of the Bay Area Rapid Transit for teachers and other consumers.

[7] He spent time in a study center for blind students in the basement of Berkeley's Moffitt Library, nicknamed "The Cave", where he recalls gaining awareness of "design and assumptions" and seeing how design choices in the world were shaped by "ableist thought behind who's in control of the tools that we use, whether those tools are intersection controls or building entrances or computer technology.

[8][6] Miele returned to university to finish his physics degree and completed a summer internship at the Smith-Kettlewell Eye Research Institute in San Francisco, where he designed and developed accessible technology for visually impaired people.

[10] Using funding from the U.S. Office of Special Education Programs, Smith-Kettlewell opened its Video Description Research and Development Center (VDRDC) in 2011, with Miele as its director.

[11] From 2011 to 2015, Miele served as president of the board of the LightHouse for the Blind and Visually Impaired, a nonprofit organization based in San Francisco.

[4] At a 2022 conference, he explained the prize money would be used to found a nonprofit organization, named the Center for Accessibility and Open Source, that would fund open-source projects for people with disabilities.

[12] Later in 2022, he was named a Distinguished Research Fellow in Disability, Accessibility, and Design at his alma mater Berkeley, to be working alongside professor Karen Nakamura.

[17][18] Miele later worked with the LightHouse for the Blind and Visually Impaired to create tactile maps of the Bay Area Rapid Transit (BART).

In developing a concept, Miele adapted a Livescribe digital pen to read off relevant information when the user taps a certain part of a tactile map, like which buses come through each bus stop.

[9][19] The LightHouse implemented Miele's concept through a four-year process which involved software design and testing, surveying transportation services, and building the maps.

That year, Miele began hosting the annual Describeathon, a one-day event held at Smith-Kettlewell during which people recorded audio descriptions.

[25][26] In a 2016 article on audio description in Representations, Berkeley professor Georgina Kleege discussed YouDescribe's benefits and potential pitfalls and her experience using the service with her students.