In addition to writing and directing, both Josh and Benny serve in a variety of key positions including acting, editing, shooting, mixing sound, and producing their films.

They have also frequently collaborated with Ronald Bronstein, who has co-written and edited all of their narrative features beginning with the 2009 film Daddy Longlegs.

Other recurring collaborators include composer Oneohtrix Point Never, cinematographer Sean Price Williams, and production designer Sam Lisenco.

[5] At Boston University, they co-founded the creative collective Red Bucket Films with Alex Kalman, Sam Lisenco, Brett Jutkiewicz, and Zachary Treitz.

[20] Starring Ronald Bronstein, it was inspired by the filmmakers' younger years living with their father, Alberto.

[25] The film centers around the real-life stories written in a book titled Mad Love in New York City by lead actress Arielle Holmes.

[29] The Safdies directed Uncut Gems, starring Adam Sandler, with Martin Scorsese serving as an executive producer.

"[34] In February 2020, Showtime ordered a pilot for The Curse, a show about the making of an HGTV-style reality series, starring Emma Stone, Nathan Fielder and Benny Safdie.

[37] The project, co-written by both brothers, was said to be set in the world of sports memorabilia,[38] and was rumored to co-star Ben Affleck, Steve Harvey, Megan Thee Stallion and Gael Garcia Bernal.

"[40] By July 2023, it was reported that Benny would not co-direct the film, marking the first time since The Pleasure of Being Robbed either of the brothers have directed solo.

[41] In January 2024, Benny confirmed that the brothers would no longer be directing projects together, as they expanded to solo careers.