He played college football for the Maryland Terrapins and was selected by the Seattle Seahawks in the second round of the 2007 NFL draft.

A graduate of DeMatha Catholic High School, Wilson saw action in all 11 games as a true freshman and became a starting cornerback late in his sophomore year, a job he never relinquished.

[3][4] During a week three home game against the Cincinnati Bengals, Wilson returned the opening kickoff 72 yards to help set up a Matt Hasselbeck touchdown pass to Bobby Engram.

[8] In the 2011 season, Wilson started in all 16 games recording 62 combined tackles, 15 pass break-ups, two interceptions, and one forced fumble.

[14] In the Week 7 game against the New York Giants, he recorded his first interception of the season; making this the second time in a row he picked off Eli Manning since their last meeting in 2011.

[15] Wilson would manage to force a fumble, which was recovered by DeJon Gomes in a Week 12 win against the Dallas Cowboys on Thanksgiving.

[16] In 2013, Wilson had a particularly poor performance against the San Francisco 49ers, where he lost several times to Anquan Boldin and Vernon Davis in one-on-one coverage.