Josiah Sandford Brigham (August, 1818 – June 10, 1892) was an American-born physician and political figure in Quebec.
He represented Missisquoi in the Legislative Assembly of Quebec from 1867 to 1875 as a Conservative.
He was born in St. Albans, Vermont, the son of Elbridge Brigham, and was educated at the St. Albans Academy, at Vermont Medical College and McGill University.
Brigham served as governor for the College of Physicians and Surgeons of Lower Canada.
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