[3][4][5][6] In a paper from 2014 further study was suggested to show if it is useful,[7] but the 2018 guideline by the European Thyroid Association for the diagnosis of uncertain cases of central hypothyroidism regarded it as beneficial.

[1] as a z-transformed value incorporating mean (2.7) and standard deviation (0.676) of TSHI in a reference population[5] The TSH index is reduced in patients with secondary hypothyroidism resulting from thyrotropic insufficiency.

A positive correlation of JTI to SIQALS 2,[16] a score for allostatic load, suggests that thyroid hormones are among the mediators linking stress to major cardiovascular endpoints.

[citation needed] In subjects with type 2 diabetes, treatment with beta blockers resulted in increased TSH index, but the mechanism is unclear.

[27] Negative correlation of Jostel's TSH index to the urinary excretion of certain phthalates suggests that endocrine disruptors may affect the central set point of thyroid homeostasis.

[28] Drugs that reduce the TSH index, probably via effects on the central set point of the feedback loop, include mirtazapine[29] and oxcarbazepine.