The journal was originally established as the Journal of Chronic Diseases in 1955 as a follow-up to Harry S. Truman's 1951 Presidential Task Force on national health concerns and the subsequently written Magnuson Report.

[2] Under the editorial leadership of Alvan Feinstein and Walter O. Spitzer, the title of the journal was changed to the Journal of Clinical Epidemiology with the January 1988 issue.

[3] The current editors are André Knottnerus (Netherlands School of Primary Care Research) and Peter Tugwell (University of Ottawa).

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