As one of two official journals of ISEV, the other being the Journal of Extracellular Biology, JEV covers research on lipid bilayer-delimited particles known as extracellular vesicles (EVs).

EVs are released from cells and include endosome-origin exosomes and plasma membrane-derived ectosomes/microvesicles.

The founding editors-in-chief were Clotilde Théry (Institut Curie), Yong Song Gho (Pohang University of Science and Technology), and Peter Quesenberry (Brown University).

JEV considers research articles as well as review articles, short communications, technical notes, hypotheses, position papers, editorials, and letters to the editor.

These include position papers of ISEV as well as the periodically updated consensus guidelines for the EV field, which are based on expert opinion and crowdsourcing.