It was established in 1910 by the British geneticists William Bateson and Reginald Punnett and is one of the oldest genetics journals.

On Haldane's death in 1964, his second wife Helen Spurway continued to publish the journal with Madhav Gadgil, H. Sharat Chandra, and Suresh Jayakar as editors until Spurway died in 1977 and the journal ceased publication.

With the permission of Naomi Mitchison, Haldane's sister, it was revived in 1985 and has been published by the Indian Academy of Sciences, currently in collaboration with Springer Science+Business Media, since then.

[3] It adopted the "Continuous Article Publication" (CAP) mode from January 2019.

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