[1] The journal has published important papers in pathology and experimental medicine including work by Rudolf Virchow and Ilya Ilyich Mechnikov, both of whom contributed to the inaugural issue.

In January 1999, the first of an ongoing series of Annual Review issues was published, on the topic of "Molecular and Cellular Themes in Cancer Research", edited by Peter A.

[5] The journal publishes research papers, reviews, commentaries, and perspectives, as well as the abstracts of the Pathological Society Winter and Summer Meetings (in two separate online-only yearly supplements).

The journal is published on behalf of the Pathological Society by John Wiley & Sons.

Peter Hall stood down as the Editor in Chief in late 2014 after 7 years.