It was established in 1967 and is published by the American Society for Microbiology.

Research papers are available free online 6 months after print publication.

The current editors-in-chief are Felicia Goodrum (University of Arizona) and Stacey Schultz-Cherry (St. Jude Children's Research Hospital).

[1] Past editors-in-chief include Rozanne M. Sandri-Goldin (University of California, Irvine, California) (2012-2022),[2] Lynn W. Enquist (2002–2012), Thomas Shenk (1994–2002), and Arnold J. Levine (1984–1994).

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