[1][2] For his performance as Hooded Justice in Watchmen, he was nominated for the Primetime Emmy Award for Outstanding Supporting Actor in a Limited Series or Movie.

[5] His maternal grandfather Fatai Adepo was special adviser to former Nigerian President Olusegun Obasanjo.

Adepo studied acting under the tutelage of a variety of notable instructors, including Ben Guillory of The Robey Theatre Company and Dianne Hull of the Actors Studio.

[14] Adepo was "the only member of the Fences cast who did not star in the play's 2010 Broadway revival before it made the jump to feature film.

"[15] In 2017, he appeared as the central character[16] along with Wyatt Russell in Overlord, both playing American paratroopers confronted by Nazi super soldiers.

[11] Adepo played the role of Larry Underwood in the 2020 miniseries adaptation of Stephen King's The Stand.

[1][12] In November 2019, he appeared as the central character in the sixth episode of Watchmen, playing the world's first superhero, Hooded Justice.