He made 111 Uruguayan Primera División appearances for Cerro, Peñarol, Montevideo Wanderers, Liverpool and Nacional, winning the league in 2022 and 2023 for the last two clubs, respectively.

[2] Izquierdo made his professional debut for Cerro on 20 February 2018, starting in a goalless draw away to Sport Rosario of Peru in the Copa Sudamericana, under manager Fernando Correa.

[2] He played just five times for the club managed by Diego López, who finished as league runners-up to Uruguayan Clásico rivals Nacional.

[7] His team reached the Torneo Intermedio final, losing in a penalty shootout to Nacional, and finished the league season in 5th and qualifying for the Copa Libertadores.

[2] Izquierdo moved to Nacional for 2022, playing just 13 minutes as a substitute against Rentistas on 13 February in a league-winning season due to a tibia stress fracture.

[12] Sāo Paulo FC players wore a jersey in support before the team's 2–1 Brazilian league win against Vitória on 25 August.

[17] According to Izquierdo's mother, the hospital staff said that her son had a virus that had entered his heart and caused the cardiac arrhythmia due to the physical exertion of the match.

[17] Alejandro Domínguez, the president of CONMEBOL, also extended his condolences to Izquierdo's family and friends and said that "South American football is in mourning".