Juan Manuel Cajigal y Odoardo (1803 in Barcelona, Anzoátegui – 1856 in Yaguaraparo, Sucre) was a Venezuelan mathematician, engineer and statesman.
Orphaned at age 7, he was raised in Spain by his cousin-once-removed, Field Marshal Juan Manuel Cajigal, former captain general of Venezuela and Cuba.
He helped found the Sociedad Económica de Amigos del País the following year, and in 1830 the government appointed him to create and direct the new Military Academy of Mathematics.
With José Hermenegildo García and Fermín Toro he started the newspaper Correo de Caracas, which ran from 1838 to 1841.
His publications include Tratado de mecánica elemental ("Treatise on Fundamental Mechanics") and Curso de astronomía y memorias sobre integrales entre límites ("Course on Astronomy and Report on Integrals between Limits").