[4][2] De Quesada was appointed Governor and intendant of Honduras in 1783, and remained in this office until 1789, when he was replaced in the Honduran government by Alejo García Conde.
[1] Upon his appointment, De Quesada wrote to George Washington informing the president of his new position in Florida and offering his diplomatic friendship to the United States.
[10] De Quesada banned the recognition of runaway slaves who had fled from the American South to Florida seeking freedom.
Through commissioner James Seagrove of Georgia, De Quesada wrote a letter initiating the agreement that stated any American slaveowner immigrating to Florida simply had to swear that they were the legitimate owners of the enslaved person for their ownership to be recognized.
[11] He became ill in February 1796, and continued to serve as governor of East Florida only until March of that year, when he was succeeded by Bartolomé Morales.