He received his Bachelor of Arts degree from the Ateneo de Manila and his Licentiate in Medicine and Surgery from the University of Santo Tomas.

He worked as a consulting physician of the Mary Johnston Hospital before entering politics.

[2] Nolasco first joined politics as a member of the Manila City Council from 1916 to 1919.

In 1931, he was elected to the Philippine Senate to represent the 4th District, and served until the abolition of the body in 1935.

[2] In August 1941, he was appointed by President Manuel L. Quezon as Mayor of Manila[3] and served in that position until December, shortly after the beginning of the Japanese invasion.