Juan Ponce de León II (1524–1591)[1] was a Spanish official and an acting governor of Puerto Rico.

Ponce de León II was sent by the Spanish Crown to establish a settlement on the island of Trinidad in 1569.

In 1570, this settlement was abandoned, possibly because of the raids by the Caribs, which resulted in the death of Ponce de Leon's son.

[3] In 1581, at the request of King Philip II of Spain, Juan Lopez Melgarejo, who served as governor of Puerto Rico from 1581 to 1582, asked Juan Ponce de León II to write a general description of the West Indies with emphasis on the part corresponding to Puerto Rico.

In 1581, Ponce de León II was able to establish the exact geographical coordinates of San Juan by observing an eclipse.