In 1489, Juan Ruiz de Medina was selected by the King of Spain and confirmed by Pope Innocent VIII as Bishop of Astorga.
On March 27, 1493, he was appointed by Pope Alexander VI as Bishop of Badajoz.
On 20 February 1495, he was appointed by Pope Alexander VI as Bishop of Cartagena.
[1] In 1502, he was appointed by Pope Alexander VI as Bishop of Segovia.
[1] He served as Bishop of Segovia until his death on 30 January 1507.