Juan de Sanabria (1504-1549) was a Spanish Nobleman, Captain and Conquistador.

[2] In 1547, Sanabria was appointed as Adelantado of the Río de la Plata, he died while preparing trip to America.

His son Diego de Sanabria, remained in charge of the expedition.

[3] Juan de Sanabria was the husband of Mencía Calderón Ocampo, the first expeditionary woman of the New World, who arrived in Paraguayan territory six years after having left Spain.

She was accompanied by his daughters, and a contingent of 80 soldiers, 40 Spanish women and some children.