[2] The Manso family's liberal political ideologies soon caused trouble for them when the Rosas government came into power, and in 1840 Manso and the rest of her family were forced from their home in Buenos Aires and exiled to Montevideo, Uruguay (where she first published a few of her poems in a local newspaper, El Nacional, in 1841)[1]—only to have to flee to Brazil in 1841; initially staying in Rio Grande do Sul, then settling more permanently in Rio de Janeiro.

[2] Eventually she turned the journal over to another Brazilian feminist, Violante A. Ximenes de Bivar e Vellasco to continue publishing and editing.

[2] Facing financial hardship, Manso, for a short time, humored the idea of attending the Medical School of Rio de Janeiro to become a midwife, only for the plan to fall through.

[2] Subsequently, after Juan Manuel de Rosas's fall from power, Manso would finally return to Buenos Aires in 1853 for the first time since her family's exile.

[1] A further advancement in 1868 saw Manso become a member of Argentina's Board of Public Instruction, making her the first woman to ever be appointed to a position in the Argentine government.