She is known for playing April O'Neil in Teenage Mutant Ninja Turtles (1990) and Gwen Cromwell Piper in the Disney Channel television film series Halloweentown, from 1998 to 2006.

[citation needed] After leaving Loving in 1988, Hoag began her career in primetime television, and in next year won female lead role on CBS comedy series Wolf.

[5] After Teenage Mutant Ninja Turtles fame, Hoag starred in a number of pilots not picked up as a series, and appeared in several television films, including Fine Things by Danielle Steel, and Switched at Birth opposite Bonnie Bedelia.

In a 2020 Galaxy Con question-and-answer panel, Hoag revealed she had a meeting with the head of Walt Disney Television where she read for the part and got cast in the role after it was revealed that the head's son was a die-hard Ninja Turtle fan as Hoag had previously played April O'Neil in 1990's Teenage Mutant Ninja Turtles.

[6] She also appeared in the films Armageddon (1998), Flying By (2009), I Am Number Four (2011) and Hitchcock (2012),[7] and has made over 60 guest appearances on television shows, including Quantum Leap, Melrose Place, Roseanne, The Nanny, Murder, She Wrote, Chicago Hope, The X-Files, Six Feet Under, Ghost Whisperer, NYPD Blue, Grey's Anatomy, Private Practice, CSI: NY, Criminal Minds, Sons of Anarchy, Castle, The Middle, Grimm and among other notable television series.

In 2012, Hoag was cast in a recurring role in the ABC drama series Nashville created by Academy Award winner Callie Khouri.