Since the early 1980s, Ross has photographed a cross-section of the American population, especially people in eastern Pennsylvania where she was born and raised.

Ross uses an 8×10 inch view camera mounted on a tripod and her portraits are made on printing out paper by contact, a process by which a print is made by placing a negative directly onto photographic paper, and then exposing it to sunlight for a few minutes to a few hours.

Her series include pictures of children at Eurana Park in Weatherly, Pennsylvania (1982), visitors to the Vietnam Veterans Memorial in Washington D.C. (1983–1984), members of the United States Congress and their aides in their Washington offices (1986–1987), laborers, people at shopping malls, and children at play near her home in Bethlehem, Pennsylvania.

John Szarkowski at the Museum of Modern Art in New York selected Ross' work for the first exhibition in the New Photography series.

In 2011, Die Photographische Sammlung in Cologne organized a retrospective exhibition of Ross's work which traveled to the Kunstmuseum Kloster in Madeburg and the Foundation A Stichting, Brussels.