Rapoport's research group at NIMH also studies clinical phenomenology, neurobiology, and treatment of childhood-onset schizophrenia.

She completed internships at Mount Sinai Hospital (Manhattan) in New York, New York, and psychiatric residencies at Massachusetts Mental Health Center in Boston, Massachusetts and St. Elizabeths Hospital in Washington, D.C. She received additional research training at NIMH's Laboratory of Psychology[2] in Bethesda, Maryland.

Rapoport's research group at NIMH studies the clinical phenomenology, neurobiology, and treatment of childhood-onset schizophrenia.

In addition to her research at NIH, she holds academic appointments in psychiatry at the George Washington University School of Medicine & Health Sciences[3] and Georgetown University School of Medicine, both in Washington, D.C. Rapoport is a member of a number of advisory committees of national professional medical organizations, including the National Anxiety Foundation and the American Psychopathological Association, for which she served as president.

She has also authored and coauthored several professional medical books, more than 300 scientific research papers, and more than 200 journal articles.