Judith with the Head of Holofernes is a c. 1495 glue tempera on canvas painting by Andrea Mantegna, now in the National Gallery of Ireland in Dublin.

This painting is part of the grisaille production that characterized many works of Mantegna in the later years of his career, from c. 1495 to the end of his life.

At the time, near Mantua, there was a scarcity of active sculptors and it was difficult to procure marble, which had to be imported from nearby territories.

Judith with the Head of Holofernes was acquired in Italy at an unknown time in the 20th century by Lewis Strange Wingfield.

In the first years of its display to the public and to scholars, skepticism about the work circulated, despite the high opinions of Bernard Berenson and Paul Kristeller [it] (both wrote about it in 1901).