It was written by singer Julian Casablancas and produced by David Kahne.

The song was released by RCA Records as the lead single from the Strokes' third studio album, First Impressions of Earth.

Casablancas was quoted in Spin as saying this about the song: "I remember people saying this track's ugly, I think it's got a great personality."

The track was leaked long before its scheduled single release,[2] forcing the band and managers to release it as a single in iTunes format earlier than planned.

The video for "Juicebox", directed by Michael Palmieri with cinematography by Christopher Doyle, features comedian David Cross as a DJ in a radio station in New York City.