They have performed this song on several programs, including The Tonight Show with Jay Leno and Late Night with Conan O'Brien.

A cover of Marvin Gaye's "Mercy Mercy Me" was recorded as a B-side and features Eddie Vedder of Pearl Jam sharing vocals with Casablancas, while Josh Homme (of Queens of the Stone Age, Them Crooked Vultures and Eagles of Death Metal) plays drums alongside Fabrizio Moretti.

The Strokes' Myspace page asked all users to put the song in their profile in an attempt to spread the single among the online community.

Julian Casablancas commented on the video saying, "People tell us all the time we're gonna die from smoking, but you only live once," implying that the room is the band members' lungs and the water is tobacco tar.

An alternate music video for the song, which was directed by Warren Fu, was premiered on the social media site imeem on May 29, 2007.