[2][3] The music for the song was written primarily by KMFDM frontman Sascha Konietzko, who asked returning band member Raymond Watts to write the lyrics for "Juke-Joint Jezebel" as well as a few other tracks from Nihil.

[5] When mixing the song, Konietzko thought it sounded too "awful" to be included on Nihil, but TVT Records, to whom KMFDM were signed at the time, wanted to put it on the album, certain it would become a hit.

[6] In KMFDM's profile for Trouser Press, Neil Strauss highlights Watts' lyrics and looped guitar riffs and electro-funk beats as the song's main features.

In addition to this, the "sleazy and exuberant" chorus features a harmonic use of the Mixolydian mode, which seems to "set the song apart from industrial conventions," with lyrics describing pleasure from self-destruction, "tapping into shallow perceptions of religious fervor and lasciviousness.

The Canadian release of Juke-Joint Jezebel: The Giorgio Moroder Mixes includes a bonus CD titled The Year of the Pig Collection, which features one track each from KMFDM's previous six studio albums, as well "Fuck Me" from Sin Sex & Salvation.

[24] Andy Hinds of AllMusic, mentioning the song in the main album's review, called it "an enduring and indispensable dancefloor favorite at goth/industrial clubs around the world.