Her articles have appeared in The Washington Post, The New York Times, The New Yorker, Foreign Policy, Forbes, Bloomberg Businessweek, The New Republic, Politico, and The Atlantic.
In a college newspaper column published in 2003, she was quoted as supporting Israel's "methods of defense against terrorism", including the construction of the Israeli West Bank Wall.
[26] Ioffe covered protests and the political manoeuvring surrounding Vladimir Putin's return to the presidency, in her column "Kremlinology 2012," which was published in Foreign Policy.
[28] During the most violent protest, which took place on May 6, 2012, the day before Putin's inauguration, Ioffe took a photo of a small boy on a bicycle with training wheels, facing a row of Russian riot police.
[36] Ioffe continued writing about Russia, including about the 2013 anti-gay laws[37] and the Kremlin's ban on American adoptions of Russian children.
"[58] The tweet had included a link to a CNN news article claiming the president elect was planning to assign the East Wing of the White House, traditionally the First Lady's domain, to his eldest daughter Ivanka.
[56] On December 6, 2016, The Atlantic announced that it was hiring Ioffe to cover national security, foreign policy, and politics, with editor-in-chief Jeffrey Goldberg describing her as "an indefatigable reporter, a gifted analyst, and an elegant writer".
[59] She wrote about The Atlantic obtaining a 10-month correspondence between Donald Trump Jr. and WikiLeaks, which played a pivotal role in the presidential campaign and was suspected by the US intelligence community of being "chosen by the Russian government to disseminate the information it had hacked".
[60] Ioffe gained access to the entire e-mail correspondence between Trump's campaign chief Paul Manafort and Oleg Deripaska, a Russian oligarch with strong ties to the Kremlin.
According to the piece: "Manafort attempted to leverage his leadership role in the Trump campaign to curry favor with a Russian oligarch close to Vladimir Putin".
[63] Melania Trump, however, wrote in a Facebook post: "There are numerous inaccuracies in this article ... My parents are private citizens and should not be subject to Ms. Ioffe's unfair scrutiny.
"[65] Ioffe's profile was praised by Slate and Erik Wemple,[63][64] while Fox News writer Howard Kurtz said it had a "condescending tone".
[69][70] On October 29, 2018, Ioffe appeared on CNN's The Lead with Jake Tapper, where she took part in a discussion about President Trump's rhetoric in the wake of the Pittsburgh synagogue shooting.
Joe Coscarelli of New York magazine wrote that "[Ioffe's] simple, bullet-pointed list of arguments would never be allowed on cable television because they reveal an ability to think outside a black or white, good or bad, America or Russia dichotomy".
[80] Philip Bump of The Atlantic assumed that it's "impossible to win a TV Argument in an Internet World", that "the power distinction between host and guest became flexible… [because] they interact both on-air and off" and "nearly any writing online could similarly rise to national attention" like Ioffe's.
[79] In November 2019, Ioffe accused a writer on the Arkansas Democrat-Gazette on Twitter of being a Russian troll after noticing one of its stories about Hunter Biden used a symbol that she mistakenly identified as a Russian-style quotation mark.