He took his first victory with the team in March 2012, when he took the general classification at the Driedaagse van West-Vlaanderen after teammate Michał Kwiatkowski withdrew from the race on the final day.

[14] At the 2014 Tour of Britain, Vermote won the seventh stage of the race, having made a solo attack from a five-rider breakaway group with around 17 kilometres (11 miles) remaining.

[15] A week later, Vermote won a bronze medal at the UCI Road World Championships, as part of the Omega Pharma–Quick-Step squad riding in the team time trial.

Vermote had been a part of the breakaway, which was later joined by a group of overall contenders on the hilly route, before he was the only other rider to follow an attack by Steve Cummings on the run-in to Kendal.

[17] Vermote pulled clear of Cummings on the final climb to the line, taking the leader's jersey as well as the stage win.

[2] Over the next two seasons, Vermote recorded three top-ten individual placings; finishing ninth at Kuurne–Brussels–Kuurne – being part of a breakaway that was caught with 100 metres (330 feet) remaining[22] – and eighth at the Grand Prix d'Isbergues in 2018, and tenth at Paris–Tours in 2019.

[23] He then joined Cofidis for the 2020 season (who were returning to the top level of cycling as a UCI WorldTeam),[24] where he worked largely as a domestique during the COVID-19 pandemic-effected campaign.