According to 2000 federal census data, Juniata County School District served a resident population of 22,273 people.

By 2013, the US Census reports that the Juniata County School District's resident population grew to 24,005 people.

Juniata County high school students may choose to attend Mifflin-Juniata Career and Technology Center for training in the construction and mechanical trades.

The Tuscarora Intermediate Unit IU11 provides the district with a wide variety of services like specialized education for disabled students and hearing, speech and visual disability services, employee background checks and professional development for staff and faculty.

The Juniata County School District offers a wide variety of clubs, activities and sports.