Fuente has coached quarterbacks as an assistant or head coach including three-time Pro Bowler Andy Dalton, first-round draft pick Paxton Lynch, and arena football quarterback Jerod Evans.

Fuente attended Union High School in Tulsa and played football as a quarterback, where he threw for 6,104 yards and 65 touchdowns.

[8] However, after Oklahoma opened the season with a loss to TCU, Blake named Fuente the starting quarterback.

[12] At Murray State, Fuente was named the Ohio Valley Conference Offensive Player of the Year and a finalist for the Walter Payton Award following the 1999 season.

[13] Following his graduation from Murray, Fuente signed a contract with the Oklahoma Wranglers of the Arena Football League.

[17] At TCU, he was promoted to co-offensive coordinator in 2009, and under his guidance both helped develop Andy Dalton at quarterback and lead the Horned Frogs to an undefeated season and victory in the 2011 Rose Bowl.

[6] The University of Memphis named Fuente its head coach on December 8, 2011, replacing Larry Porter.

[19] In February 2013, Memphis extended the term of Fuente's contract through the 2017 season as a result of the gains he made in his first year as head coach of the Tigers.

[23] Fuente's contract was extended and he received a raise at the close of the 2014 season for a total of a 5-year deal at approximately $1.4 million per year.

[24] Virginia Tech named Fuente its head coach on November 29, 2015, replacing the retiring Frank Beamer.

Virginia Tech and Fuente agreed to mutually part ways with two games remaining in the 2021 season after losses to Boston College, Syracuse, Notre Dame, and Pittsburgh.